Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC029
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-26 12:43
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.65 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.65 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 3, 'TN': 5, 'TP': 39, 'FP': 25}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 1, 'TN': 1, 'TP': 41, 'FP': 29}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 5, 'TP': 37, 'FP': 25}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 4.33333
timePerCircleCoV 0.121412
timePerCircleSlope -0.0387692
meanError 1.84904
tremorFreq 6.44531
tremorRelPower 24.4812
tremorGyroAmpMean 0.0200505
tremorGyroAmpSlope -0.0269756
tremorGyroAmpCoV 0.451104
tremorCoordAmpMean 0.0650519
tremorCoordAmpSlope 0.0298634
tremorCoordAmpCoV 1.19305
tremorAccAmpMean 0.0449205
tremorAccAmpSlope 0.00281066
tremorAccAmpCoV 0.428698
tremorPcRelVar 0.940293
tremorPcX -0.905342
tremorPcY -0.424684

Circle Segment 1

Duration 5.16 s, Accuracy Estimate 1.625 (lower is better)

Circle Segment 2

Duration 4.68 s, Accuracy Estimate 1.792 (lower is better)

Circle Segment 3

Duration 4.24 s, Accuracy Estimate 1.73 (lower is better)

Circle Segment 4

Duration 4.92 s, Accuracy Estimate 1.79 (lower is better)

Circle Segment 5

Duration 4.32 s, Accuracy Estimate 1.888 (lower is better)

Circle Segment 6

Duration 4.12 s, Accuracy Estimate 1.531 (lower is better)

Circle Segment 7

Duration 4.24 s, Accuracy Estimate 1.727 (lower is better)

Circle Segment 8

Duration 3.88 s, Accuracy Estimate 1.514 (lower is better)

Circle Segment 9

Duration 3.44 s, Accuracy Estimate 3.044 (lower is better)

Spiral

numSpirals 11
timePerSpiralMean 13.3673
timePerSpiralCoV 0.0727687
timePerSpiralSlope -0.00133297
meanError 1.91211
tremorFreq 6.83594
tremorRelPower 31.4574
tremorGyroAmpMean 0.0441757
tremorGyroAmpSlope -0.000287903
tremorGyroAmpCoV 0.342682
tremorCoordAmpMean 0.0875154
tremorCoordAmpSlope 0.0015817
tremorCoordAmpCoV 0.294004
tremorAccAmpMean 0.066495
tremorAccAmpSlope 0.00131559
tremorAccAmpCoV 0.324032
tremorPcRelVar 0.703219
tremorPcX -0.189263
tremorPcY 0.981926

Spiral Segment 1

Duration 13.92 s, Accuracy Estimate 1.768 (lower is better)

Spiral Segment 2

Duration 13.0 s, Accuracy Estimate 2.055 (lower is better)

Spiral Segment 3

Duration 12.16 s, Accuracy Estimate 1.912 (lower is better)

Spiral Segment 4

Duration 13.28 s, Accuracy Estimate 1.897 (lower is better)

Spiral Segment 5

Duration 14.92 s, Accuracy Estimate 1.86 (lower is better)

Spiral Segment 6

Duration 14.44 s, Accuracy Estimate 1.944 (lower is better)

Spiral Segment 7

Duration 13.6 s, Accuracy Estimate 1.925 (lower is better)

Spiral Segment 8

Duration 12.68 s, Accuracy Estimate 1.942 (lower is better)

Spiral Segment 9

Duration 11.72 s, Accuracy Estimate 2.189 (lower is better)

Spiral Segment 10

Duration 13.12 s, Accuracy Estimate 1.786 (lower is better)

Spiral Segment 11

Duration 14.2 s, Accuracy Estimate 1.754 (lower is better)

Elel

eDurationMean 0.470937
eDurationStd 0.0694075
eDurationStdnorm 0.147381
eDurationMedian 0.45
eDurationQuartdelta 0.145
eDurationQuartdeltanorm 0.322222
eDurationKurt 1.38881
eDurationTrenddiff -0.11
eDurationTrendratio 0.797235
eWidthMean 5.55019
eWidthStd 1.99426
eWidthStdnorm 0.359313
eWidthMedian 5.0895
eWidthQuartdelta 2.5155
eWidthQuartdeltanorm 0.494253
eWidthKurt 3.12758
eWidthTrenddiff 0.936
eWidthTrendratio 1.21333
eHeightMean 12.5994
eHeightStd 1.42831
eHeightStdnorm 0.113363
eHeightMedian 12.6945
eHeightQuartdelta 1.5795
eHeightQuartdeltanorm 0.124424
eHeightKurt 3.07144
eHeightTrenddiff 1.053
eHeightTrendratio 1.08612
eAspectMean 0.439134
eAspectStd 0.137988
eAspectStdnorm 0.314228
eAspectMedian 0.378252
eAspectQuartdelta 0.209685
eAspectQuartdeltanorm 0.554354
eAspectKurt 2.29952
eAspectTrenddiff 0.10005
eAspectTrendratio 1.27689
eSlantMean 0.152864
eSlantStd 0.152912
eSlantStdnorm 1.00032
eSlantMedian 0.133475
eSlantQuartdelta 0.23597
eSlantQuartdeltanorm 1.7679
eSlantKurt 1.8973
eSlantTrenddiff 0.0944164
eRtopMean 0.766414
eRtopStd 0.105521
eRtopStdnorm 0.137682
eRtopMedian 0.77695
eRtopQuartdelta 0.129062
eRtopQuartdeltanorm 0.166114
eRtopKurt 2.67396
eRtopTrenddiff 0.047946
eRbotMean 0.486849
eRbotStd 0.237888
eRbotStdnorm 0.488627
eRbotMedian 0.466261
eRbotQuartdelta 0.4133
eRbotQuartdeltanorm 0.886413
eRbotKurt 1.91135
eRbotTrenddiff -0.139907
eRrightMean 0.895948
eRrightStd 0.0727806
eRrightStdnorm 0.081233
eRrightMedian 0.9095
eRrightQuartdelta 0.063333
eRrightQuartdeltanorm 0.069635
eRrightKurt 5.99676
eRrightTrenddiff -0.0177493
eRleftMean 0.273185
eRleftStd 0.0736901
eRleftStdnorm 0.269744
eRleftMedian 0.272597
eRleftQuartdelta 0.119561
eRleftQuartdeltanorm 0.438601
eRleftKurt 2.11226
eRleftTrenddiff -0.00592192
lDurationMean 0.60375
lDurationStd 0.11196
lDurationStdnorm 0.185441
lDurationMedian 0.585
lDurationQuartdelta 0.16
lDurationQuartdeltanorm 0.273504
lDurationKurt 2.37611
lDurationTrenddiff -0.1075
lDurationTrendratio 0.836502
lWidthMean 10.3472
lWidthStd 2.55763
lWidthStdnorm 0.247181
lWidthMedian 10.0035
lWidthQuartdelta 3.627
lWidthQuartdeltanorm 0.362573
lWidthKurt 2.77892
lWidthTrenddiff 0.702
lWidthTrendratio 1.07059
lHeightMean 27.4731
lHeightStd 1.94385
lHeightStdnorm 0.0707549
lHeightMedian 27.963
lHeightQuartdelta 2.808
lHeightQuartdeltanorm 0.100418
lHeightKurt 3.95643
lHeightTrenddiff 0.351
lHeightTrendratio 1.01261
lAspectMean 0.375865
lAspectStd 0.0840982
lAspectStdnorm 0.223746
lAspectMedian 0.370392
lAspectQuartdelta 0.101984
lAspectQuartdeltanorm 0.275341
lAspectKurt 3.11718
lAspectTrenddiff 0.0260454
lAspectTrendratio 1.07254
lSlantMean 0.216418
lSlantStd 0.100343
lSlantStdnorm 0.463656
lSlantMedian 0.1938
lSlantQuartdelta 0.129832
lSlantQuartdeltanorm 0.66993
lSlantKurt 2.69792
lSlantTrenddiff 0.0213458
lRtopMean 0.873325
lRtopStd 0.0594899
lRtopStdnorm 0.0681189
lRtopMedian 0.881366
lRtopQuartdelta 0.083864
lRtopQuartdeltanorm 0.0951523
lRtopKurt 2.48511
lRtopTrenddiff 0.00786269
lRbotMean 0.315237
lRbotStd 0.132673
lRbotStdnorm 0.420868
lRbotMedian 0.286111
lRbotQuartdelta 0.212158
lRbotQuartdeltanorm 0.741524
lRbotKurt 2.03867
lRbotTrenddiff 0.0374958
lRrightMean 0.915206
lRrightStd 0.0505547
lRrightStdnorm 0.0552386
lRrightMedian 0.926123
lRrightQuartdelta 0.057811
lRrightQuartdeltanorm 0.0624226
lRrightKurt 3.48976
lRrightTrenddiff 0.0416294
lRleftMean 0.139222
lRleftStd 0.0425646
lRleftStdnorm 0.305732
lRleftMedian 0.13818
lRleftQuartdelta 0.0528291
lRleftQuartdeltanorm 0.38232
lRleftKurt 2.90284
lRleftTrenddiff -0.0287001

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

FITTS Short Modified

meanTouchScore 0.943988
sumTouchScores 26.4317
meanMovementTime 0.669444
numTouches 28
undershootPercentage 0
overshootPercentage 17.8571

FITTS Long Modified

meanTouchScore 0.942255
sumTouchScores 19.7874
meanMovementTime 0.9215
numTouches 21
undershootPercentage 0
overshootPercentage 4.7619

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 12.208
timePerZigzagCoV 0.0364418
timePerZigzagSlope -0.0203145
meanError 2.52913
tremorFreq 5.95703
tremorRelPower 30.2579
tremorGyroAmpMean 0.0575536
tremorGyroAmpSlope -0.00633332
tremorGyroAmpCoV 0.353041
tremorCoordAmpMean 0.126558
tremorCoordAmpSlope -0.00841736
tremorCoordAmpCoV 0.418672
tremorAccAmpMean 0.0905269
tremorAccAmpSlope -0.00801314
tremorAccAmpCoV 0.334728
tremorPcRelVar 0.740403
tremorPcX -0.48349
tremorPcY 0.87535

ZigZag Segment 1

Duration 12.92 s, Accuracy Estimate 2.687 (lower is better)

ZigZag Segment 2

Duration 12.24 s, Accuracy Estimate 2.59 (lower is better)

ZigZag Segment 3

Duration 12.0 s, Accuracy Estimate 2.45 (lower is better)

ZigZag Segment 4

Duration 12.16 s, Accuracy Estimate 2.251 (lower is better)

ZigZag Segment 5

Duration 11.72 s, Accuracy Estimate 2.667 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 8.616
timePerZigzagCoV 0.0899381
timePerZigzagSlope -0.0487465
zigzagHeightMean 65.5793
zigzagHeightCoV 0.0987375
zigzagHeightSlope 0.0589921
meanError 0.0359683
tremorFreq 6.05469
tremorRelPower 27.813
tremorGyroAmpMean 0.0732317
tremorGyroAmpSlope -0.000111115
tremorGyroAmpCoV 0.309342
tremorCoordAmpMean 0.137967
tremorCoordAmpSlope 0.0016969
tremorCoordAmpCoV 0.225382
tremorAccAmpMean 0.109916
tremorAccAmpSlope 0.00134301
tremorAccAmpCoV 0.251787
tremorPcRelVar 0.751752
tremorPcX -0.435915
tremorPcY 0.899988

ZigZag Offset Segment 1

Duration 9.92 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 2

Duration 8.4 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 3

Duration 8.6 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 4

Duration 8.28 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 5

Duration 7.88 s, Accuracy Estimate 0.05 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.77}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.65}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.5089452978968552}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8600171686397919}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}